Abstract ofJournal Article -- March 2005
By Emilie Attwell Becker, MD; Alan Shafer, PhD; and Rhonda
Psychiatrists commonly treat adolescents with multiple
psychotropic medications simultaneously. We studied the effects of
psychotropic medications on the weight of adolescent patients at
Austin State Hospital between June 1997 and December 2001. The
medication combinations that caused the largest weight increases
were olanzapine with valproic acid, and olanzapine with
venlafaxine. The biggest weight loss combinations were valproic
acid with bupropion, and valproic acid with venlafaxine.
Medications drove a substantial portion of the changes in weight,
not other variables. The specific medication prescribed, rather
than the total number of medications, predicted weight gain. As
current inpatient adolescents are receiving multiple medications
and their weight is subsequently being affected, more study is
needed to better understand these effects.