Early Detection of Prostate Cancer: Is PSA a Reliable Option?

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Abstract of Journal Article -- February 2001  

Symposium on Cancer: What Primary Care Physicians Need to Know  

By Koji Okihara, MD; and R. Joseph Babaian, MD  

A close relationship exists between prostate volume and prostate-specific antigen (PSA). Clinical decisions must be determined based on the variability of PSA. Screening with the PSA assay has contributed to early detection of prostate cancer. Some important undetermined issues are the optimal cutoff values of PSA, the proportion of free to total PSA, and the clinical usefulness of complexed PSA. Current articles demonstrating novel markers (human kallikrein-2, BPSA, and pro PSA) and artificial neural networks are introduced.

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